*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL7540000
CHEMICAL NAME           : 1-Piperazineethanol,
                          4-(3-(2-chlorophenothiazin-10-yl)propyl)-, and
                          10,11-dihydro-N,N-
                          dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup
                          5,gamma)-propylamine
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H26-Cl-N3-O-S.1/5C20-H23-N
MOLECULAR WEIGHT        : 460.45
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Amitriptyline and perphenazine (5:1)
   * Perphenazine and amitriptyline (1:5)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 10 mg/kg
SEX/DURATION            : female 30-31 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,282,1973
 
                            *** END OF RECORD ***