*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL9730000
CHEMICAL NAME           : 1-Piperazineethanol,
                          4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-
CAS REGISTRY NUMBER     : 69-23-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C22-H26-F3-N3-O-S
MOLECULAR WEIGHT        : 437.57
WISWESSER LINE NOTATION : T C666 BN ISJ EXFFF B3- AT6N DNTJ D2Q
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Elinol
   * Fluorfenazine
   * Fluphenazine
   * Ftorphenazine
   * 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
   * Pacinol
   * Phenothiazine,  
   10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)-
   * Phthorphenazine
   * 1-Piperazineethanol,  
   4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-
   * S94
   * Sevinol
   * Siqualon
   * SQ 4918
   * Triflumethazine
   * 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
   * Valamina
   * Vespazine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,540,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Autonomic Nervous System - central sympatholytic
   Behavioral - alteration of classical conditioning
REFERENCE :
   MDCHAG Medicinal Chemistry: A Series of Monographs.  (Academic Press, Inc.,
   1 E. First St., Duluth, MN 55802)  V.1-    1963-  Volume(issue)/page/year:
   4(2),199,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,540,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 89 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - coma
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 145,450,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,540,1960
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 62 mg/kg
SEX/DURATION            : female 9 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,338,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 18 mg/kg
SEX/DURATION            : female 9 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,338,1967

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMSCA9 Journal of Mental Science.  (London, UK)  V.4-108, 1857-1962.  For
   publisher information, see BJPYAJ.  Volume(issue)/page/year: 106,755,1960

   TOXICOLOGY REVIEW
   IDPYAK Industrial Pharmacology.  (Mount Kisco, NY)  V.1-3, 1974-79.
   Discontinued.  Volume(issue)/page/year: 1,203,1974

 
                            *** END OF RECORD ***