*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL9900000
CHEMICAL NAME           : 1-Piperazineethanol,
                          4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl
                          )-
CAS REGISTRY NUMBER     : 2709-56-0
LAST UPDATED            : 199507
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H25-F3-N2-O-S
MOLECULAR WEIGHT        : 434.56
WISWESSER LINE NOTATION : T C666 BS IYJ IU3- AT6N DNTJ D2Q
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Emergil
   * Fluanxol
   * Flupenthixol
   * (alpha,beta)-Flupenthixol
   * Flupenthixole
   * Flupentixol
   * Fluxanxol
   * LC 44
   * N 7009
   * 1-Piperazineethanol,  
   4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-
   * Siplaril
   * Siplarol
   *   2-Trifluoromethyl-9-(3-(4-(beta-hydroxyethyl)-1-piperazinyl)propylidene)
     thioxanthene
   *   4-(3-(2-(Trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethan
     ol
   *   4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazinee
     thanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 900 ug/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - changes in motor activity (specific assay)
   Behavioral - coma
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 15,388,1981
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 367 ug/kg/12D-I
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - muscle weakness
   Behavioral - headache
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,93,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,2121,1977
 
                            *** END OF RECORD ***