*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TM1774200 CHEMICAL NAME : Piperazine, 1-methyl-4-(o-methyl-alpha-phenylbenzyl)-, dihydrochloride CAS REGISTRY NUMBER : 24342-56-1 LAST UPDATED : 198609 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H24-N2.2Cl-H MOLECULAR WEIGHT : 353.37 WISWESSER LINE NOTATION : T6N DNTJ AYR&R B1& D1 &GH 2 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * ortho-Methylcyclizine dihydrochloride * 1-Methyl-4-(o-methyl-alpha-phenylbenzyl)piperazine dihydrochloride * Piperazine, 1-methyl-4-((2-methylphenyl)phenylmethyl)-, dihydrochloride * Piperazine, 1-methyl-4-(alpha-o-tolylbenzyl)-, dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 142 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,17,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,17,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,17,1958 *** END OF RECORD ***