*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM1774200
CHEMICAL NAME           : Piperazine,
                          1-methyl-4-(o-methyl-alpha-phenylbenzyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 24342-56-1
LAST UPDATED            : 198609
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H24-N2.2Cl-H
MOLECULAR WEIGHT        : 353.37
WISWESSER LINE NOTATION : T6N DNTJ AYR&R B1& D1 &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * ortho-Methylcyclizine dihydrochloride
   * 1-Methyl-4-(o-methyl-alpha-phenylbenzyl)piperazine dihydrochloride
   * Piperazine, 1-methyl-4-((2-methylphenyl)phenylmethyl)-, dihydrochloride
   * Piperazine, 1-methyl-4-(alpha-o-tolylbenzyl)-, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 116,17,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 116,17,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 116,17,1958
 
                            *** END OF RECORD ***