*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM2663030
CHEMICAL NAME           : 1-Piperazinepropanol,
                          4-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-
CAS REGISTRY NUMBER     : 30297-71-3
BEILSTEIN REFERENCE NO. : 0899488
REFERENCE               : 5-23-02-00433 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H25-Cl-N2-O-S
MOLECULAR WEIGHT        : 388.99
WISWESSER LINE NOTATION : T C676 BS&T&J FG I- AT6N DNTJ D3Q
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-1-piperazinepropanol
   *   8-Chloro-10-(4-(3-hydroxypropyl)piperazino)-10,11-dihydrodibenzo(b,f)thi
     epin
   * Oxyclothepin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,719,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 38,1190,1973
 
                            *** END OF RECORD ***