*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM4569320
CHEMICAL NAME           : Piperidine,
                          3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl
                          )-, hydrochloride, (3S-trans)-
CAS REGISTRY NUMBER     : 78246-49-8
LAST UPDATED            : 199509
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H20-F-N-O3.Cl-H
MOLECULAR WEIGHT        : 365.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Paroxetine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 415 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASSUA6 Acta Psychiatrica Scandinavica, Supplementum.  (Munksgaard
   International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark)  No.160-
   1961-  Volume(issue)/page/year: 350,31,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASSUA6 Acta Psychiatrica Scandinavica, Supplementum.  (Munksgaard
   International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark)  No.160-
   1961-  Volume(issue)/page/year: 350,31,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 378 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASSUA6 Acta Psychiatrica Scandinavica, Supplementum.  (Munksgaard
   International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark)  No.160-
   1961-  Volume(issue)/page/year: 350,31,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ASSUA6 Acta Psychiatrica Scandinavica, Supplementum.  (Munksgaard
   International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark)  No.160-
   1961-  Volume(issue)/page/year: 350,31,1989
 
                            *** END OF RECORD ***