*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM5650000
CHEMICAL NAME           : 1-Piperidinebutyronitrile,
                          alpha-sec-butyl-alpha-phenyl-, hydrochloride
CAS REGISTRY NUMBER     : 53198-87-1
LAST UPDATED            : 199506
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H28-N2.Cl-H
MOLECULAR WEIGHT        : 320.95
WISWESSER LINE NOTATION : T6NTJ A2XR&CN&Y2&1 &GH
SYNONYMS/TRADE NAMES :
   * alpha-sec-Butyl-alpha-phenyl-1-piperidinebutyronitrile hydrochloride
   * Eurazyl
   * alpha-Phenyl-alpha-(2-piperidinoethyl)beta-ethylbutyric acid nitrile  
   hydrochloride
   * alpha-Phenyl-alpha-(2-piperidinoethyl)-beta-ethylbutyronitrile  
   hydrochloride
   * R 154
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,673,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,298,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,673,1958
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,298,1960
 
                            *** END OF RECORD ***