*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM6140000
CHEMICAL NAME           : 4-Piperidinecarboxylic acid,
                          1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl
                          ester, monohydrochloride, mixt. with
                          endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-
                          (hydroxymethyl)benzeneacetate sulfate (2:1) (salt)
CAS REGISTRY NUMBER     : 55840-97-6
LAST UPDATED            : 199403
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C30-H32-N2-O2.C17-H23-N-O3.Cl-H.1/2H2-O4-S
MOLECULAR WEIGHT        : 827.46
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Atropine sulfate and diphenoxylate hydrochloride
   * Diphenoxylate-atropine
   * Lomotil
   * Reasec
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1212 ug/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 2,377,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 5250 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 87,694,1991
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1515 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,150,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 2300 ug/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (British Medical Journal, POB
   560B, Kennebunkport, ME 04046)  V.1-    1926-  Volume(issue)/page/year:
   54,222,1979
 
                            *** END OF RECORD ***