*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TM6140000 CHEMICAL NAME : 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha- (hydroxymethyl)benzeneacetate sulfate (2:1) (salt) CAS REGISTRY NUMBER : 55840-97-6 LAST UPDATED : 199403 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C30-H32-N2-O2.C17-H23-N-O3.Cl-H.1/2H2-O4-S MOLECULAR WEIGHT : 827.46 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Atropine sulfate and diphenoxylate hydrochloride * Diphenoxylate-atropine * Lomotil * Reasec *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 1212 ug/kg TOXIC EFFECTS : Behavioral - coma Cardiac - other changes Lungs, Thorax, or Respiration - other changes REFERENCE : CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 2,377,1969 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 5250 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - excitement Behavioral - ataxia REFERENCE : PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 87,694,1991 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 1515 ug/kg TOXIC EFFECTS : Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,150,1969 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 2300 ug/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 54,222,1979 *** END OF RECORD ***