*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TM7067000 CHEMICAL NAME : Piperidine, 3,4-dichloro-1-nitroso- CAS REGISTRY NUMBER : 57541-72-7 BEILSTEIN REFERENCE NO. : 1564951 REFERENCE : 5-20-03-00574 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C5-H8-Cl2-N2-O MOLECULAR WEIGHT : 183.05 WISWESSER LINE NOTATION : T6NTJ ANO CG DG COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * 3,4-Dichloronitrosopiperidine * N-Nitroso-3,4-dichloropiperidine *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 169 mg/kg/30W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors REFERENCE : ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 92,221,1978 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 366 mg/kg/15W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,3209,1975 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 260 mg/kg/21W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,3325,1980 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,131,1977 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 nmol/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 57,85,1978 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 200 umol/L/24H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,27,1979 TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100 umol/L REFERENCE : TCMUE9 Topics in Chemical Mutagenesis. (Plenum Pub. Corp., 233 Spring Street, New York, NY 10013) V.1- 1984- Volume(issue)/page/year: 1,129,1984 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test *** END OF RECORD ***