*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TM7630000 CHEMICAL NAME : Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-, hydrochloride, d- CAS REGISTRY NUMBER : 631-06-1 LAST UPDATED : 198910 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H23-N-O2.Cl-H MOLECULAR WEIGHT : 345.90 WISWESSER LINE NOTATION : T6MTJ B- DT5O COTJ BR& BR &GH -D COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * CL-911C * Dexoxadrol hydrochloride * d-Dioxadrol hydrochloride * d-2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine hydrochloride * d-2,2-Diphenyl-4-(2-piperidyl)-1,3-dioxolane hydrochloride * NSC-526062 * Relane * U-22,559A *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Behavioral - analgesia REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 118,352,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965 *** END OF RECORD ***