*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TM7870500 CHEMICAL NAME : Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, citrate (1:1) CAS REGISTRY NUMBER : 14698-07-8 LAST UPDATED : 198806 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C15-H17-N-S2.C6-H8-O7 MOLECULAR WEIGHT : 467.59 WISWESSER LINE NOTATION : T6N CYTJ A1 CUY- BT5SJ&- BT5SJ &QV1XQVQ1VQ COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Asverin-C * Asverin citrate * Asverine citrate * AT 327 citrate * Bithiodine * 3-(Di-2-thienylmethylene)-1-methylpiperidine citrate * 1-Methyl-3-(di-2-thienylmethylene)piperidine citrate * Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 867 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,3279,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(3),69S,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 376 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 *** END OF RECORD ***