*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM9850000
CHEMICAL NAME           : 1-Piperidineethanol, alpha-(5-phenyl-3-isoxazolyl)-,
                          citrate (1:1)
CAS REGISTRY NUMBER     : 14838-45-0
LAST UPDATED            : 199509
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C16-H20-N2-O2.C6-H8-O7
MOLECULAR WEIGHT        : 464.52
WISWESSER LINE NOTATION : T6NTJ A1YQ- ET5NOJ CR &QV1XQVQ1VQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 3-(1-Hydroxy-2-piperidinoethyl)-5-phenylisoxazole citrate
   * Isoxazole, 3-(1-hydroxy-2-piperidinoethyl)-5-phenyl-, citrate
   * 3-Isoxazolemethanol, alpha-(piperidinomethyl)-5-phenyl-, citrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 416 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Nutritional and Gross Metabolic - body temperature decrease
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 10,411,1967
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 240 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 60 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 240 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 900 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972
 
                            *** END OF RECORD ***