Title: Ceftezole
CAS Registry Number: 26973-24-0
CAS Name: (6R,7R)-8-Oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7-(1H-tetrazol-1-yl)acetamido-3-(1,3,4-thiadiazol-2-ylthio)methylceph-3-em-4-carboxylic acid; CTZ
Manufacturers' Codes: CG-B3Q
Molecular Formula: C13H12N8O4S3
Molecular Weight: 440.48
Percent Composition: C 35.45%, H 2.75%, N 25.44%, O 14.53%, S 21.84%
Literature References: Broad spectrum antibiotic similar to cefazolin, q.v. Prepn: T. Takano et al., ZA 6804513; eidem, US 3516997 (1969, 1970 both to Fujisawa). In vitro and in vivo activity: T. Noto et al., J. Antibiot. 29, 1058 (1976). Pharmacology: Y. Harada et al., ibid. 1071; M. Kakimoto et al., Chemotherapy (Tokyo) 24, 722 (1976). Metabolism: K. Koyama et al., ibid. 619; Y. Tohira et al., ibid. 655. Clinical study: S. Ishiyama et al., ibid. 1006. Toxicity and teratogenicity studies: R. Niki et al., ibid. 671.
Properties: Solid, mp 155° (dec). uv max (phosphate buffer pH 6.4): 273 nm (E1%1cm 274).
Melting point: mp 155° (dec)
Absorption maximum: uv max (phosphate buffer pH 6.4): 273 nm (E1%1cm 274)
Derivative Type: Sodium salt
CAS Registry Number: 41136-22-5
Manufacturers' Codes: FR-10123
Trademarks: Celoslin (Hoechst); Falomesin (Chugai)
Molecular Formula: C13H11N8NaO4S3
Molecular Weight: 462.46
Percent Composition: C 33.76%, H 2.40%, N 24.23%, Na 4.97%, O 13.84%, S 20.80%
Properties: White solid, freely sol in water.
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins. |