Title: Chlorotoxin
CAS Registry Number: 163515-35-3
Additional Names: ClTx; Ctx
Literature References: Small neurotoxic peptide (36 amino acids) isolated from the venom of the scorpion, Leiurus quinquestriatus characterized by 4 disulfide linkages. Specific blocker of small conductance chloride channels. Isoln, purification, and characterization: J. A. DeBin et al., Am. J. Physiol. 264, C361 (1993). Solid phase synthesis: J. Najib et al., 3rd Int. Symp. 1993 Innovation Perspect. Solid Phase Synth. Collect. Pap. 1994, 615. NMR and secondary structure: G. Lippens et al., ibid. 583; and solution structure: eidem, Biochemistry 34, 13 (1995). Identification of chloride channel in gliomas: N. Ullrich et al., Neuroscience 83, 1161 (1998); inhibition of glioma cell invasion: J. Deshane et al., J. Biol. Chem. 278, 4135 (2003). Use in cell topography: G. Tobasnick, A. S. G. Curtis, Eur. Cells Materials 2, 49 (2001).
Use: Biochemical probe for voltage-gated chloride channels. |