Title: Colestipol
CAS Registry Number: 26658-42-4
CAS Name: N-(2-Aminoethyl)-Nยข-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine polymer with (chloromethyl)oxirane
Literature References: A basic anion exchange resin described as a high molecular wt copolymer of diethylenetriamine and 1-chloro-2,3-epoxypropane (hydrochloride), with approx 1 out of 5 amine nitrogens protonated, for which no structural formula has been assigned and for which no specific mol wt information is available, due to the highly cross-linked and insoluble nature of the material. Prepn: Nelson, Van den Berg, DE 1927336; eidem, US 3692895 (1969, 1971 to Upjohn); Lednicer, Peery, DE 2053585; eidem, US 3803237 (1971, 1974 to Upjohn). Activity studies: Parkinson et al., Atherosclerosis 11, 531 (1970); 17, 167 (1973); Marmo et al., G. Arterioscler. 8, 229 (1970); Goodman et al., J. Clin. Invest. 52, 2646 (1973). Toxicology: Webster, Bollert, Toxicol. Appl. Pharmacol. 28, 57 (1974). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 19, 161-180 (1980).
Derivative Type: Hydrochloride
CAS Registry Number: 37296-80-3
Manufacturers' Codes: U-26597A
Trademarks: Cholestabyl (Fournier); Colestid (Pfizer); Lestid (Pfizer)
Properties: Light yellow, hygroscopic resin. Insol in water. Swells when suspended in water or aqueous fluids. LD50 in rats (mg/kg): >4000 i.p.; >1000 orally (Webster, Bollert).
Toxicity data: LD50 in rats (mg/kg): >4000 i.p.; >1000 orally (Webster, Bollert)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Bile Acid Sequesterants; Ion-exchange Resin. |