Title: Ethinamate
CAS Registry Number: 126-52-3
CAS Name: 1-Ethynylcyclohexanol carbamate
Additional Names: carbamic acid 1-ethynylcyclohexyl ester; ethynylcyclohexyl carbamate
Trademarks: Valamin (Schering AG); Valmid (Lilly); Valmidate
Molecular Formula: C9H13NO2
Molecular Weight: 167.21
Percent Composition: C 64.65%, H 7.84%, N 8.38%, O 19.14%
Literature References: Prepn: Junkmann, Pfeiffer, US 2816910 (1957 to Schering, AG).
Properties: Needles from cyclohexane, mp 96-98°. bp3 118-122°. Shows no optical activity. nD21.5 1.4441 (20% in propylene glycol). Soly at 25° in water 0.25%, ethanol 35.0%, hexane 2.0%, sesame oil 0.7%, 1,2-propylene glycol 22%. Stable in N H2SO4 at 30°, but dec at 40° and in 0.02N acid at 60°. In 0.01N NaOH, CO2 is split off at 30°. Lowers the surface tension in satd aq soln at 22° by 21%. Partition coefficient (oil/water): 1.48.
Melting point: mp 96-98°
Boiling point: bp3 118-122°
Index of refraction: nD21.5 1.4441 (20% in propylene glycol)
Log P: Partition coefficient (oil/water): 1.48
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14. Note: The trademark Valamin was used formerly to indicate a brand of tert-amyl isovalerate.
Therap-Cat: Sedative; hypnotic.
Keywords: Sedative/Hypnotic; Carbamates. |