Title: Gestodene
CAS Registry Number: 60282-87-3
CAS Name: (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one
Additional Names: 17a-ethynyl-17b-hydroxy-18-methyl-4,15-estradien-3-one; 17a-ethynyl-13-ethyl-17b-hydroxy-4,15-gonadien-3-one
Manufacturers' Codes: SH B 331
Molecular Formula: C21H26O2
Molecular Weight: 310.43
Percent Composition: C 81.25%, H 8.44%, O 10.31%
Literature References: Orally active gestogen with progesterone-like profile of activity. Prepn: BE 847090; H. Hofmeister et al., US 4081537 (1977, 1978 both to Schering AG). Pharmacokinetics: B. Duesterberg et al., Contraception 24, 673 (1981); B. Duesterberg, Steroids 43, 43 (1984). Comparative study of anti-aldosterone activity: W. Losert et al., Arzneim.-Forsch. 35, 459 (1985). Clinical trial as oral contraceptive: G. Hoppe, Adv. Contracept. 3, 159 (1987).
Properties: Crystals from acetone-hexane, mp 197.9°.
Melting point: mp 197.9°
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 109852-02-0
Trademarks: Femodene (Schering AG); Femovan (Schering AG); Ginoden (Schering AG); Gynera (Schering AG); Harmonet (Wyeth); Meliane (Schering AG); Milvane (Schering AG); Minulet (Wyeth); Phaeva (Schering AG); Tri-Minulet (Wyeth)
Therap-Cat: Progestogen. In combination with estrogen as oral contraceptive.
Keywords: Contraceptive (Oral); Progestogen. |