Title: Gold Sodium Thiosulfate
CAS Registry Number: 15283-45-1
CAS Name: Trisodium (T-4)-bis[monothiosulfato(2-)-kO,kS]-aurate(3-)
Additional Names: hyposulfite of gold and sodium; sodium aurothiosulfate
Trademarks: Aurocidin; Aurolin (UCB); Crisalbine; Fosfocrisolo (Zambon); Sanocrysin
Molecular Formula: AuNa3O6S4
Molecular Weight: 490.19
Percent Composition: Au 40.18%, Na 14.07%, O 19.58%, S 26.17%
Line Formula: Na3Au(S2O3)2
Literature References: Prepn of dihydrate: Fordos, Gélis, Ann. Chim. Phys. 13, 394 (1845); H. Brown, J. Am. Chem. Soc. 49, 958 (1927); Roger's Inorganic Pharmaceutical Chemistry, T. O. Soine, C. O. Wilson, Eds. (Lea & Febiger, Philadelphia, 8th ed., 1967) pp 343-345. Crystal structure of dihydrate: H. Ruben et al., Inorg. Chem. 13, 1836 (1974). Efficacy of antidotes: M. A. Basinger et al., J. Rheumatol. 12, 274 (1985). Clinical study of contact allergy patch test reactions: K. E. McKenna et al., Contact Dermatitis 32, 143 (1995). Clinical evaluation in rheumatoid arthritis: M. L. Ciompi et al., Reumatismo 54, 251 (2002).
Derivative Type: Dihydrate
CAS Registry Number: 33614-49-2
Properties: White, glistening, needle-like or prismatic crystals. d 3.14. Darkens slowly on exposure to light. One gram dissolves in 2 ml water. Insol in alc and most other organic solvents. A 1:20 aq soln is neutral or slightly alkaline to litmus. LD50 i.p. in mice: 110 mg/kg (Basinger).
Density: d 3.14
Toxicity data: LD50 i.p. in mice: 110 mg/kg (Basinger)
CAUTION: Potential symptoms of overexposure via therapeutic i.m. administration are dermatitis, nausea, vomiting, diarrhea, nephritis, blood disorders, peripheral neuritis, hepatitis, encephalitis. See Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) p II-144.
Therap-Cat: Antirheumatic; diagnostic aid (contact allergen).
Keywords: Antiarthritic/Antirheumatic; Diagnostic Aid. |