Title: Meobentine
CAS Registry Number: 46464-11-3
CAS Name: N-[(4-Methoxyphenyl)methyl]-N¢,N¢¢-dimethylguanidine
Additional Names: 1-(p-methoxybenzyl)-2,3-dimethylguanidine
Molecular Formula: C11H17N3O
Molecular Weight: 207.27
Percent Composition: C 63.74%, H 8.27%, N 20.27%, O 7.72%
Literature References: Antidysrhythmic, antifibrillatory deriv of guanidine, q.v. Prepn of the sulfate: R. A. Maxwell, E. Walton, DE 2030693 corresp to US 3949089 (1971, 1976 both to Burroughs Wellcome). Antidysrhythmic effects and tissue concentration: K. B. Touw et al., Pharmacologist 19, 268 (1977); K. B. Touw, Diss. Abstr. B 39, 5340 (1979). Pharmacokinetics by radioimmunoassay: J. W. A. Findlay et al., Pharmacologist 21, 337 (1979). Pharmacological study: W. B. Wastila et al., J. Pharm. Pharmacol. 33, 594 (1981).
Derivative Type: Sulfate
CAS Registry Number: 58503-79-0
Trademarks: Rythmatine (Burroughs Wellcome)
Molecular Formula: (C11H17N3O)2.H2SO4
Molecular Weight: 512.62
Percent Composition: C 51.55%, H 7.08%, N 16.39%, O 18.73%, S 6.26%
Properties: Cryst, mp 273-274°.
Melting point: mp 273-274°
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic. |