Title: Nifuroxazide
CAS Registry Number: 965-52-6
CAS Name: 4-Hydroxybenzoic acid [(5-nitro-2-furanyl)methylene]hydrazide
Additional Names: p-hydroxybenzoic acid (5-nitrofurfurylidene)hydrazide; 1-(p-hydroxybenzoyl)-2-(5-nitrofurfurylidene)hydrazine; 5-nitro-2-furaldehyde p-hydroxybenzoylhydrazone
Manufacturers' Codes: RC-27109
Trademarks: Adral (Lifepharma); Bacifurane (Meram); Diarlidan (Vinas); Dicoferin; Ercefurol; Ercefuryl (Sanofi-Synthelabo); Pentofuryl (Karlspharma)
Molecular Formula: C12H9N3O5
Molecular Weight: 275.22
Percent Composition: C 52.37%, H 3.30%, N 15.27%, O 29.07%
Literature References: Prepn: FR 1327840 (1963 to Robert et Carriere), C.A. 59, 12763b (1963); M. C. E. Carron, GB 962706; idem, US 3290213 (1964, 1966 both to Robert et Carriere). Antiseptic and antibacterial properties: M. C. E. Carron et al., Ann. Pharm. Fr. 21, 287 (1963). In vitro study of activity spectrum: A. Thabaut, J. L. Durosoir, Gaz. Med. Fr. 85, 4516 (1978), C.A. 90, 1487 (1979).
Properties: Crystals from pyridine, mp 298°. Practically insol in water.
Melting point: mp 298°
Therap-Cat: Intestinal antiseptic. |