Title: Pentigetide
CAS Registry Number: 62087-72-3
CAS Name: N2-[1-[N-(N-L-a-Aspartyl-L-seryl)-L-a-aspartyl]-L-prolyl]-L-arginine
Additional Names: human IgE pentapeptide; HEPP
Trademarks: Pentyde (Immunetech)
Molecular Formula: C22H36N8O11
Molecular Weight: 588.57
Percent Composition: C 44.89%, H 6.17%, N 19.04%, O 29.90%
Literature References: Synthetic pentapeptide with antiallergic activity. Structure corresponds to amino acids 320-324 of the epsilon chain of human immunoglobulin E (IgE). Prepn: R. N. Hamburger, DE 2602443; idem, US 4171299 (1976, 1979 both to Univ. California). Inhibition of IgE-mediated immediate hypersensitivity response: idem, Science 189, 389 (1975). Stimulation of peritoneal macrophages: E. Tzehoval et al., Proc. Natl. Acad. Sci. USA 75, 3400 (1978). Mechanism of action study: R. N. Hamburger, Immunology 38, 781 (1979). Clinical evaluations in allergic rhinitis: G. A. Cohen et al., Ann. Allergy 52, 83 (1984); B. M. Prenner, ibid. 58, 332 (1987).
Properties: [a]D20 -78.6° (c = 1 in water).
Optical Rotation: [a]D20 -78.6° (c = 1 in water)
Therap-Cat: Antiallergic.
Keywords: Antiallergic. |