Title: Phenyltoloxamine
CAS Registry Number: 92-12-6
CAS Name: N,N-Dimethyl-2-[2-(phenylmethyl)phenoxy]ethanamine
Additional Names: N,N-dimethyl-2-(a-phenyl-o-tolyloxy)ethylamine; N,N-dimethyl-2-(a-phenyl-o-toloxy)ethylamine; 2-(2-dimethylaminoethoxy)diphenylmethane; 2-benzhydryl b-dimethylaminoethyl ether; 2-benzylphenyl b-dimethylaminoethyl ether; PRN; bistrimin
Manufacturers' Codes: C-5581H
Trademarks: Antin; Phenoxadrine
Molecular Formula: C17H21NO
Molecular Weight: 255.35
Percent Composition: C 79.96%, H 8.29%, N 5.49%, O 6.27%
Literature References: Prepn: Cheney et al., J. Am. Chem. Soc. 71, 60 (1949); Binkley, Cheney, US 2703324 (1955 to Bristol Labs.).
Properties: Oily liquid, bp 141-144° (at <0.1 mm Hg).
Boiling point: bp 141-144° (at <0.1 mm Hg)
Derivative Type: Dihydrogen citrate
Molecular Formula: C17H21NO.C6H8O7
Molecular Weight: 447.48
Percent Composition: C 61.73%, H 6.53%, N 3.13%, O 28.60%
Properties: Crystals from water or methanol, mp 138-140°. Soluble in water.
Melting point: mp 138-140°
Derivative Type: Hydrochloride
Molecular Formula: C17H21NO.HCl
Molecular Weight: 291.82
Percent Composition: C 69.97%, H 7.60%, N 4.80%, O 5.48%, Cl 12.15%
Properties: Crystals from methyl isobutyl ketone, mp 119-121°. Soluble in water.
Melting point: mp 119-121°
Therap-Cat: Dihydrogen citrate as antihistaminic.
Keywords: Antihistaminic; Aminoalkylethers. |