Title: Remifentanil
CAS Registry Number: 132875-61-7
CAS Name: 4-(Methoxycarbonyl)-4-[(1-oxopropyl)phenylamino]-1-piperidinepropanoic acid methyl ester
Additional Names: 4-carboxy-4-(N-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester; remifentanyl
Manufacturers' Codes: GI-87084
Molecular Formula: C20H28N2O5
Molecular Weight: 376.45
Percent Composition: C 63.81%, H 7.50%, N 7.44%, O 21.25%
Literature References: Synthetic mu-opioid agonist. Prepn: P. L. Feldman et al., EP 383579; eidem, US 5019583 (1990, 1991 both to Glaxo); eidem et al., J. Med. Chem. 34, 2202 (1991). Opioid receptor activity: M. K. James et al., J. Pharmacol. Exp. Ther. 259, 712 (1991). Pharmacology: W. E. Hoffman et al., Anesthesiology 79, 107 (1993). Clinical pharmacokinetics: T. D. Egan et al., ibid. 881; C. L. Westmoreland et al., ibid. 893. HPLC determn in blood: K. Selinger et al., J. Pharm. Biomed. Anal. 12, 243 (1994). Review of safety of bolus injection: S. P. Richardson, T. D. Egan, Expert Opin. Drug Saf. 4, 643-651 (2005).
Derivative Type: Hydrochloride
CAS Registry Number: 132539-07-2
Manufacturers' Codes: GI-87084B
Trademarks: Ultiva (Glaxo Wellcome)
Molecular Formula: C20H28N2O5.HCl
Molecular Weight: 412.91
Percent Composition: C 58.18%, H 7.08%, N 6.78%, O 19.37%, Cl 8.59%
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic). |