Title: Suxibuzone
CAS Registry Number: 27470-51-5
CAS Name: Butanedioic acid mono[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester
Additional Names: succinic acid monoester with 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester); 1,2-diphenyl-4-n-butyl-4-hydroxymethyl-3,5-dioxopyrazolidine hemisuccinate; 4-hydroxymethylbutazolidine hemisuccinate
Manufacturers' Codes: AE-17
Trademarks: Calibène (Delalande); Danilon (Esteve); Flogos (Gentili); Solurol (Delalande)
Molecular Formula: C24H26N2O6
Molecular Weight: 438.47
Percent Composition: C 65.74%, H 5.98%, N 6.39%, O 21.89%
Literature References: Prodrug of phenylbutazone, q.v. Prepd (not claimed) and use as anti-inflammatory: A. Esteve, DE 1936747; idem, US 3752894 (1970, 1973 both to Lab. Esteve). Pharmacology: A. Esteve et al., Quim. Ind. (Madrid) 17, 107 (1971). HPLC determn in plasma and urine: T. Marunaka et al., J. Pharm. Sci. 69, 1258 (1980). Metabolism in humans: Y. Yasuda et al., ibid. 71, 565 (1982). Comparative clinical study with phenylbutazone in rheumatoid arthritis: Y. Mizushima et al., Int. J. Tissue React. 5, 35 (1983).
Properties: White, bitter crystalline powder from alcohol, mp 126-127°. Sol in most organic solvents. Insol in water. LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973).
Melting point: mp 126-127°
Toxicity data: LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973)
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Analgesic, antipyretic, anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Pyrazolones. |