Title: Tetranectin
CAS Registry Number: 109489-77-2
Literature References: Tetrameric protein isolated from human plasma. Enhances plasminogen activation catalyzed by tissue plasminogen activator, q.v. Composed of four identical, non-covalently bound, polypeptide chains each containing 181 amino acids, with mol wt 20,100 daltons. Isoln from human serum: I. Duhl Clemmensen, C. Kluft, EP 206400 (1986 to Ned. Cent. Org. Toegepast-Natuurwetenschappelijk Onderzoek). Purification, characterization and plasminogen binding activity: I. Clemmensen et al., Eur. J. Biochem. 156, 327 (1986). Primary structure: J. Fuhlendorff et al., Biochemistry 26, 6757 (1987). Enzyme-linked immunoassay in human plasma: B. A. Jensen et al., J. Lab. Clin. Med. 110, 612 (1987). Distribution in human endocrine tissue: L. Christensen et al., Histochemistry 87, 195 (1987). Possible role in cancer metastasis: B. A. Jensen, I. Clemmensen, Cancer 62, 869 (1988).
Properties: Isoelectric point 5.8. E1%280nm 12.5. |