Title: Amineptine
CAS Registry Number: 57574-09-1
CAS Name: 7-[(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]heptanoic acid
Molecular Formula: C22H27NO2
Molecular Weight: 337.46
Percent Composition: C 78.30%, H 8.06%, N 4.15%, O 9.48%
Literature References: Dopamine uptake blocker. Prepn: C. Malen et al., DE 2011806; eidem, US 3758528 (1970, 1973 both to Sci. Union et Cie Soc. Franc. Recher. Med.). Biochemical and pharmacological study: R. Samanin et al., J. Pharm. Pharmacol. 29, 555 (1977). Effect on dopamine uptake: N. B. Mercuri et al., Br. J. Pharmacol. 104, 700 (1991). Metabolism: L. Grislain et al., Eur. J. Drug Metab. Pharmacokinet. 15, 339 (1990). HPLC determn in plasma: P. P. Rop et al., J. Chromatogr. 532, 351 (1990). Clinical trial in depression: M. Paes de Sousa, J. Tropa, Clin. Neuropharmacol. 12, Suppl. 2, S77 (1989).
Derivative Type: Hydrochloride
CAS Registry Number: 30272-08-3
Manufacturers' Codes: S-1694
Trademarks: Maneon (Poli); Survector (Eutherapie)
Molecular Formula: C22H27NO2.HCl
Molecular Weight: 373.92
Percent Composition: C 70.67%, H 7.55%, N 3.75%, O 8.56%, Cl 9.48%
Properties: Crystals from distilled water, mp 226-230°.
Melting point: mp 226-230°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics. |