Title: Cariporide
CAS Registry Number: 159138-80-4
CAS Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Additional Names: 4-isopropyl-3-(methanesulfonylbenzoyl)guanidine
Molecular Formula: C12H17N3O3S
Molecular Weight: 283.35
Percent Composition: C 50.87%, H 6.05%, N 14.83%, O 16.94%, S 11.32%
Literature References: Selective inhibitor of the sodium-hydrogen exchanger subtype 1 (NHE-1); protects against myocardial injury following ischemia and reperfusion. Prepn: H. J. Lang et al., EP 589336; eidem, US 5591754 (1994, 1997 both to Hoechst); A. Weichert et al., Arzneim.-Forsch. 47, 1204 (1997). Pharmacology: W. Scholz et al., Cardiovasc. Res. 29, 260 (1995). Symposium on pharmacology and clinical experience: Am. J. Cardiol. 83, Suppl. 10A, 1G-25G (1999). Review: W. Scholz et al., J. Thromb. Thrombolysis 8, 61-70 (1999).
Properties: Colorless solid, mp 90-94° (dec).
Melting point: mp 90-94° (dec)
Derivative Type: Methanesulfonate
CAS Registry Number: 159138-81-5
Additional Names: Cariporide mesylate
Manufacturers' Codes: HOE-642
Molecular Formula: C12H17N3O3S.CH3SO3H
Molecular Weight: 379.45
Percent Composition: C 41.15%, H 5.58%, N 11.07%, O 25.30%, S 16.90%
Properties: Colorless needles from isopropanol + water, mp 227-230°.
Melting point: mp 227-230°
Therap-Cat: Cardioprotective.
Keywords: Cardioprotective. |