Title: Collinomycin
CAS Registry Number: 27267-69-2
CAS Name: 6-[2-(4,9-Dihydro-8-hydroxy-5,7-dimethoxy-4,9-dioxonaphtho[2,3-b]furan-2-yl)ethyl]-7,8-dihydroxy-1-oxo-1H-2-benzopyran-3-carboxylic acid methyl ester
Additional Names: a-rubromycin
Molecular Formula: C27H20O12
Molecular Weight: 536.44
Percent Composition: C 60.45%, H 3.76%, O 35.79%
Literature References: Antibiotic substance produced by Streptomyces collinus: Brockmann, Renneberg, Naturwissenschaften 40, 166 (1953); DE 918162 (1954 to Bayer). Identity with a-rubromycin: Brockmann et al., Tetrahedron Lett. 1966, 3525. Structure: Brockmann, Zeeck, Ber. 103, 1709 (1970). Shows considerable in vitro-activity against Staph. aureus.
Properties: Orange prisms from chloroform-methanol, mp 280-282°. Moderately sol in chloroform, acetone, dioxane; sparingly sol in ether, low-molecular alcohols. Practically insol in petr ether, water, aq sodium bicarbonate soln.
Melting point: mp 280-282° |