Title: Fluvoxamine
CAS Registry Number: 54739-18-3
CAS Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime
Additional Names: 5-methoxy-4¢-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime
Molecular Formula: C15H21F3N2O2
Molecular Weight: 318.33
Percent Composition: C 56.60%, H 6.65%, F 17.90%, N 8.80%, O 10.05%
Literature References: Selective serotonin reuptake inhibitor (SSRI). Prepn: NL 7503310; H. B. A. Welle, V. Claassen, US 4085225 (1975, 1978 both to Philips-Duphar). Inhibition of 5-HT uptake: V. Claassen et al., Br. J. Pharmacol. 60, 505 (1977). HPLC determn in plasma: G. J. De Jong, J. Chromatogr. 183, 203 (1980). Series of articles on pharmacology, pharmacokinetics and clinical trials in depression: Br. J. Clin. Pharmacol. 15, Suppl. 3, 347S-450S (1983). Clinical trial in obsessive-compulsive disorder: L. M. Koran et al., J. Clin. Psychopharmacol. 16, 121 (1996). Review of clinical experience in depression: M. R. Ware, J. Clin. Psychiatry 58, Suppl. 5, 15-23 (1997).
Derivative Type: Maleate
CAS Registry Number: 61718-82-9
Manufacturers' Codes: DU-23000; MK-264
Trademarks: Dumirox (Solvay); Faverin (Solvay); Fevarin (Solvay); Floxyfral (Solvay); Luvox (Solvay); Maveral (Farmades)
Molecular Formula: C15H21F3N2O2.C4H4O4
Molecular Weight: 434.41
Percent Composition: C 52.53%, H 5.80%, F 13.12%, N 6.45%, O 22.10%
Properties: Crystals from acetonitrile, mp 120-121.5°. Freely sol in ethanol, chloroform; sparingly sol in water. Practically insol in diethyl ether.
Melting point: mp 120-121.5°
Therap-Cat: Antidepressant; antiobsessional.
Keywords: Antidepressant; Antiobsessional; Serotonin Uptake Inhibitor. |