Title: Grubbs' Catalyst
CAS Registry Number: 172222-30-9
CAS Name: (SP-5-31)-Dichloro(phenylmethylene)bis(tricyclohexylphosphine)ruthenium
Additional Names: benzylidenebis(tricyclohexylphosphine)ruthenium dichloride
Molecular Formula: C43H72Cl2P2Ru
Molecular Weight: 822.96
Percent Composition: C 62.76%, H 8.82%, Cl 8.62%, P 7.53%, Ru 12.28%
Literature References: Transition metal catalyst. Prepn: P. Schwab et al., Angew. Chem. Int. Ed. 34, 2039 (1995); and of related catalysts: eidem, J. Am. Chem. Soc. 118, 100 (1996). Ring-closing metathesis intoduction of carbon-carbon crosslinks in peptides: S. J. Miller et al., ibid. 9606. Mechanism of ring-opening metathesis: J. A. Tallarico et al., ibid. 119, 7157 (1997). Yne-ene cross metathesis: M. Schuster, S. Blechert, Tetrahedron Lett. 39, 2295 (1998). Review of use and prepn: A. Fürstner, Angew. Chem. Int. Ed. 39, 3012-3043 (2000).
Properties: Purple air-stable microcrystalline solid.
Use: Catalysis of olefin metathesis including ring-closing of dienes, cross metathesis and ring-opening methathesis polymerizations (ROMP). |