Title: Mequitazine
CAS Registry Number: 29216-28-2
CAS Name: 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Additional Names: 10-(3-quinuclidinylmethyl)phenothiazine
Manufacturers' Codes: LM-209
Trademarks: Butix (Fabre); Metaplexan (Rh>e-Poulenc); Mircol (Rh>e-Poulenc); Primalan (Inava); Zesulan (Toyo Jozo)
Molecular Formula: C20H22N2S
Molecular Weight: 322.47
Percent Composition: C 74.49%, H 6.88%, N 8.69%, S 9.94%
Literature References: Prepn: G. Gueremy et al., DE 2009555 corresp to US 3987042 (1970, 1976 to Sogeras). Absorption, distribution, and excretion: A. Uzan et al., Xenobiotica 6, 633 (1976). Biotransformation: eidem, ibid. 649. Pharmacologic study: eidem, J. Pharm. Pharmacol. 31, 701 (1979). Clinical studies: J. Blamoutier, Curr. Med. Res. Opin. 5, 366 (1978); P. Laugier, M. Orusco, ibid. 371.
Properties: Crystals from acetonitrile, mp 130-131°.
Melting point: mp 130-131°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Phenothiazines. |