Title: Morclofone
CAS Registry Number: 31848-01-8
CAS Name: (4-Chlorophenyl)[3,5-dimethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]methanone
Additional Names: 4¢-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone; dimeclophenone
Manufacturers' Codes: K-3712
Trademarks: Medicil (Medici); Nitux (Inpharzam); Plausitin (Erba)
Molecular Formula: C21H24ClNO5
Molecular Weight: 405.87
Percent Composition: C 62.14%, H 5.96%, Cl 8.74%, N 3.45%, O 19.71%
Literature References: Prepn: F. Lauria et al., DE 2016707 corresp to US 3708482 (1971, 1973 both to Carlo Erba). Antitussive activity in humans: E. Bosisio et al., Farmaco Ed. Prat. 26, 356 (1971).
Properties: Cryst from cyclohexane, mp 91-92°. LD50 orally in mice: 552 mg/kg (Lauria).
Melting point: mp 91-92°
Toxicity data: LD50 orally in mice: 552 mg/kg (Lauria)
Therap-Cat: Antitussive.
Keywords: Antitussive.
Status: This monograph has been retired and is no longer subject to revision or update. |