Title: Rasagiline
CAS Registry Number: 136236-51-6
CAS Name: (1R)-2,3-Dihydro-N-2-propynl-1H-inden-1-amine
Additional Names: (R)-N-2-propynyl-1-indanamine; N-propargyl-1-(R)-aminoindan
Manufacturers' Codes: AGN-1135
Molecular Formula: C12H13N
Molecular Weight: 171.24
Percent Composition: C 84.17%, H 7.65%, N 8.18%
Literature References: Irreversible MAO-B inhibitor. Prepn: M. B. H. Youdim et al., EP 436492; eidem. US 5457133 (1991, 1995 both to Teva). Pharmacology: J. P. M. Finberg, M. B. H. Youdim, Neuropharmacology 43, 1110 (2002); of metabolites: S. Glezer, J. P. M. Finberg, Eur. J. Pharmacol. 472, 173 (2003). Mechanism of action: M. B. H. Youdim et al., Biochem. Pharmacol. 66, 1635 (2003). Double-blind clinical trial as adjunctive therapy to levodopa: J. M. Rabey et al., Clin. Neuropharmacol. 23, 324 (2000); multicenter trial in early Parkinson's disease: Arch. Neurol. 59, 1937 (2002); in levodopa-treated Parkinson's patients: Parkinson Study Group, ibid. 62, 241 (2005); O. Rascol et al., Lancet 365, 947 (2005). Review of pharmacology: J. J. Chen, D. M. Swope, J. Clin. Pharmacol. 45, 878-894 (2005); of clinical development: O. Rascol, Expert Opin. Pharmacother. 6, 2061-2075 (2005); F. Stocchi, Int. J. Clin. Pract. 60, 215-221 (2006).
Derivative Type: Methanesulfonate
CAS Registry Number: 161735-79-1
Additional Names: Rasagiline mesylate
Manufacturers' Codes: TVP-1012
Trademarks: Agilect (Teva); Azilect (Teva)
Molecular Formula: C12H13N.CH3SO3H
Molecular Weight: 267.34
Percent Composition: C 58.40%, H 6.41%, N 5.24%, S 11.99%, O 17.95%
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian. |