Title: Talinolol
CAS Registry Number: 57460-41-0
CAS Name: N-Cyclohexyl-N¢-[4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]urea
Additional Names: 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane; (±)-1-[p-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea
Manufacturers' Codes: 02-115
Trademarks: Cordanum (AWD)
Molecular Formula: C20H33N3O3
Molecular Weight: 363.49
Percent Composition: C 66.09%, H 9.15%, N 11.56%, O 13.20%
Literature References: Selective b1-adrenergic blocker structurally related to practolol, q.v. Prepn: R. Eckardt et al., DE 2153024 (1972 to Arzneimittelwerke VEB), C.A. 77, 61639b (1972); idem et al., Pharmazie 30, 633 (1975). Series of articles on pharmacology, toxicology: ibid. 638-683. Acute toxicity: K. Femmer et al., ibid. 642. Clinical pharmacokinetics and bioavailability: B. Trausch et al., Biopharm. Drug Dispos. 16, 403 (1995). Review of clinical experience: I. Assmann, Curr. Med. Res. Opin. 13, 325-342 (1995).
Properties: Cryst from isopropanol, mp 142-144°. LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer).
Melting point: mp 142-144°
Toxicity data: LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer)
Therap-Cat: Antihypertensive; antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives. |