Title: Urocortin
CAS Registry Number: 176591-49-4 (human); 171543-83-2 (rat)
Literature References: Mammalian neuropeptide related to corticotropin releasing factor (CRF), q.v. Composed of 40 amino acid residues. Evokes secretion of ACTH; binds to CRF receptors and to CRF binding protein. Identification in rat brain: J. Vaughan et al., Nature 378, 287 (1995). Cloning and characterization of human urocortin: C. J. Donaldson et al., Endocrinology 137, 2167 (1996). Interaction with CRF binding protein: D. P. Behan et al., Brain Res. 725, 263 (1996). Appetite suppressing effects: M. Spina et al., Science 273, 1561 (1996). |