Title: Vedaprofen
CAS Registry Number: 71109-09-6
CAS Name: 4-Cyclohexyl-a-methyl-1-naphthaleneacetic acid
Additional Names: 2-(4-cyclohexyl-1-naphthyl)-propionic acid
Manufacturers' Codes: CERM-10202; PM-150
Trademarks: Quadrisol (Intervet)
Molecular Formula: C19H22O2
Molecular Weight: 282.38
Percent Composition: C 80.81%, H 7.85%, O 11.33%
Literature References: Propionic acid type non-steroidal anti-inflammatory drug (NSAID). Prepn: J. J. Godfroid, E. Steiner, BE 870553; eidem, US 4218473 (1979, 1980 both to CERM). Summary of field trials in dogs: J. G. H. Bergman, P. van Laar, Vet. Q. 18, S20 (1996). Pharmacodynamics and pharmacokinetics in horses: P. Lees et al., J. Vet. Pharmacol. Ther. 22, 96 (1999).
Properties: Crystals from ethyl alcohol/water, mp 150°. LD50 orally in rat: 400 mg/kg (Godfroid).
Melting point: mp 150°
Toxicity data: LD50 orally in rat: 400 mg/kg (Godfroid)
Therap-Cat-Vet: Anti-inflammatory. |