Title: Pramiracetam
CAS Registry Number: 68497-62-1
CAS Name: N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide
Additional Names: N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide; amacetam
Molecular Formula: C14H27N3O2
Molecular Weight: 269.38
Percent Composition: C 62.42%, H 10.10%, N 15.60%, O 11.88%
Literature References: Cognition enhancer structurally related to piracetam, q.v. Prepn: Y. J. L'Italien, I. C. Nordin, DE 2808067; eidem, US 4145347 (1978, 1979 both to Parke, Davis); D. E. Butler et al., J. Med. Chem. 27, 684 (1984). Pharmacology: B. P. H. Poschel et al., Drugs Exp. Clin. Res. 9, 853 (1983). GC determn in plasma: T. Chang, R. M. Young, J. Chromatogr. 274, 346 (1983). Clinical pharmacokinetics: T. Chang et al., J. Clin. Pharmacol. 25, 291 (1985). Clinical evaluation in Alzheimer's disease: R. J. Branconnier et al., Psychopharmacol. Bull. 19, 726 (1983); in various cognitive disorders: R. Dejong, Curr. Ther. Res. 41, 254 (1987).
Properties: bp0.15 162-164°. Monohydrate, mp 47-48°.
Melting point: mp 47-48°
Boiling point: bp0.15 162-164°
Derivative Type: Sulfate
CAS Registry Number: 72869-16-0
Manufacturers' Codes: CI-879
Molecular Formula: C14H27N3O2.H2SO4
Molecular Weight: 367.46
Percent Composition: C 45.76%, H 7.95%, N 11.44%, O 26.12%, S 8.73%
Properties: LD50 in male, female mice (mg/kg): 5434, 4355 orally (Poschel).
Toxicity data: LD50 in male, female mice (mg/kg): 5434, 4355 orally (Poschel)
Therap-Cat: Nootropic.
Keywords: Nootropic. |