Title: Zymosan
CAS Registry Number: 9010-72-4
Literature References: Anticomplementary factor. Crude yeast cell wall prepns consisting chiefly of protein-carbohydrate complexes. Prepn from whole yeast cells: Pillemer, Ecker, J. Biol. Chem. 137, 139 (1941); Pillemer et al., J. Exp. Med. 103, 1 (1956); from yeast cell walls: Z. Holan, Folia Microbiol. 25, 501 (1980). Composition of zymosan: F. J. DiCarlo, J. V. Fiore, Science 127, 756 (1958). Enhances the specific defenses of an organism through the activation of the properdin system, q.v. Activity studies: Brade et al., J. Immunol. 111, 1389 (1973); 112, 1115 (1974). Induces aggregation and a release reaction in human platelet-rich plasma: Zucker, Grant, ibid. 1219. Review: Fitzpatrick, DiCarlo, Ann. N.Y. Acad. Sci. 118, art. 4, 233 (1964).
Properties: Light gray powder. Practically insol in water, but readily disperses to give a homogeneous suspension.
Use: In the assay of properdin. |