Title: Atracurium Besylate
CAS Registry Number: 64228-81-5
CAS Name: 2,2¢-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzenesulfonate
Additional Names: 2-(2-carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate pentamethylene ester; N,N¢-dimethyl-N,N¢-(4,10-dioxa-3,11-dioxotridecylene)-1,13-bis-tetrahydropapaverinium dibesylate
Manufacturers' Codes: BW-33A; Wellcome 33-A-74
Trademarks: Tracrium (GSK)
Molecular Formula: C65H82N2O18S2
Molecular Weight: 1243.48
Percent Composition: C 62.78%, H 6.65%, N 2.25%, O 23.16%, S 5.16%
Literature References: Benzylisoquinolinium, competitive neuromuscular blocker. Prepn: J. B. Stenlake et al., DE 2655883; eidem, US 4179507 (1977, 1979 both to Burroughs Wellcome). Pharmacology: R. Hughes, D. J. Chapple, Br. J. Anaesth. 53, 31 (1981). Clinical pharmacology: S. J. Basta et al., Anesth. Analg. 61, 723 (1982). Neuromuscular effects in man: R. L. Katz et al., ibid. 730. Metabolic studies: E. A. Neill, D. J. Chapple, Xenobiotica 12, 203 (1982). Pharmacokinetics: S. Ward et al., Br. J. Anaesth. 55, 113 (1983). Use during halothane anesthesia in humans: J. A. Stirt et al., Anesth. Analg. 62, 207 (1983). Symposium on pharmacology, metabolism, and clinical studies: Br. J. Anaesth. 55, Suppl. 1, 1S-139S (1983); on pharmacokinetics and clinical experience: ibid. 58, Suppl. 1, 1S-113S (1986).
Properties: Off-white powder, mp 85-90°. Softens at 60°.
Melting point: mp 85-90°
Derivative Type: Cisatracurium besylate
CAS Registry Number: 96946-42-8
CAS Name: (1R,1¢R,2R,2¢R)-2,2¢-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzenesulfonate
Manufacturers' Codes: 51W89
Trademarks: Nimbex (GSK)
Literature References: Prepn: D. A. Hill, G. L. Turner, WO 9200965 (1992 to Wellcome Found.). Clinical pharmacology: C. A. Lien et al., Anesthesiology 82, 1131 (1995); M. R. Belmont et al., ibid. 1139.
Properties: White solid.
Therap-Cat: Neuromuscular blocking agent.
Therap-Cat-Vet: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents. |