美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Amlodipine Besylate/Benazepril HCl	Capsule	I (Basket)	100	0.01 N HCl	500	10, 20 , 30, 45, and 60	2007/06/20
Amlodipine Besylate/Hydrochlorothiazide/Olmesartan Medoxomil	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8	900	5, 10, 15, 20, 30 and 45	2011/07/21
Amlodipine Besylate/Hydrochlorothiazide/Valsartan	Tablet			Refer to USP			2016/07/28
Amlodipine Besylate/Olmesartan Medoxomil	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8	900	10, 20, 30 and 45	2008/08/11
Amlodipine besylate/Perindopril Arginine	Tablet	II (Teflon coated paddle)	75	0.01 N HCL	1000	5, 10, 15, 20 and 30	2016/03/17
Amlodipine Besylate/Telmisartan	Tablet	II (Paddle)	75	Telmisartan: Phosphate Buffer, pH 7.5; Amlodipine: 0.01N HCl, pH 2	Telmisartan: 900; Amlodipine: 500	Telmisartan: 10, 15, 20, 30 and 45; Amlodipine: 10, 15, 20, 30 and 45	2010/08/05
Amlodipine Besylate/Valsartan	Tablet			Refer to USP			2016/07/28
Amoxicillin	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Amoxicillin	Tablet (Extended Release)	II (Paddle)	100	3 Stage dissolution: 50 mM potassium phosphate monobasic buffer at pH 4.0 (0-2 hours), 6.0 (2-4 hours) and 6.8 ( 4 hours and beyond)	900	0.25, 0.5, 1, 2, 2.25, 2.5, 3, 4, 4.25, 4.5, 5 and 6 hours	2010/10/21
Amoxicillin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Amoxicillin	For Oral Suspension			Develop a dissolution method			2023/09/15
Amoxicillin/Clarithromycin/Lansoprazole	Capsule/Tablet/Capsule (Copackage)			Develop a dissolution method for Amoxicillin Capsules, Refer to USP for monographs of Clarithromycin Tablets and Lansoprazole Delayed-Release Capsules			2024/01/03
Amoxicillin/Clarithromycin/Omeprazole	Capsule/Tablet/Capsule (Copackage)			Develop a dissolution method for Amoxicillin Capsules, Refer to USP for monographs of Clarithromycin Tablets and Omeprazole Delayed-Release Capsules			2024/01/03
Amoxicillin/Clavulanate Potassium	Tablet			Develop a dissolution method			2024/01/03
Amoxicillin/Clavulanate Potassium	Suspension			Develop a dissolution method			2023/09/15
Amoxicillin/Clavulanate Potassium	Tablet (Chewable)			Develop a dissolution method			2023/09/15
Amoxicillin/Omeprazole Mg./Rifabutin	Capsule (Delayed Release)	I (Basket	100	Amoxicillin/Rifabutin: 0.01 N HCl; Omeprazole: 0.1N HCl; Buffer Stage: 0.05M Phosphate buffer, pH 6.8	Amoxicillin/Rifabutin:900; Omeprazole: Acid Stage: 900; Buffer Stage:900;	Amoxicillin/Rifabutin: 5, 10, 15, 20 and 30; Omeprazole: Acid Stage: 120; Buffer Stage: 5, 10, 15, 20 and 30;	2020/08/27
Amoxicillin; Clarithromycin; Vonoprazan Fumarate	Capsule, Tablet, Tablet	Clarithromycin and Vonoprazan: II (Paddle)	Clarithromycin and Vonoprazan: 50	Amoxicillin: Develop a dissolution method; Clarithromycin: 0.1M Sodium Acetate Buffer (pH 5.0); Vonoprazan: 0.05M Acetate Buffer (pH 4.5)	900	10, 15, 30, 45, 60 and 90	2024/02/05
Amoxicillin; Vonoprazan Fumarate	Capsule, Tablet	Vonoprazan: II (Paddle)	Vonoprazan: 50	Amoxicillin: Develop a dissolution method; Vonoprazan: 0.05M Acetate Buffer (pH 4.5)	900	10, 15, 30, 45, 60 and 90	2024/02/05
Amphetamine	Tablet (Extended Release, Orally Disintegrating)	II (Paddle	75	Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8	Acid Stage: 900 mL; Buffer Stage: 1000 mL	Acid Stage: 10, 15, 30, 45, 60, 90, 120; Buffer Stage: 5, 10, 15, 30 and 45	2016/07/28