Title: Perflubron
CAS Registry Number: 423-55-2
CAS Name: 1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Additional Names: bromoperfluorooctane; perfluoroctyl bromide; PFOB
Manufacturers' Codes: L-1913
Trademarks: Imagent (Alliance); LiquiVent (Alliance); Oxygent (Alliance)
Molecular Formula: C8BrF17
Molecular Weight: 498.96
Percent Composition: C 19.26%, Br 16.01%, F 64.73%
Line Formula: CF3(CF2)6CF2Br
Literature References: Synthetic second generation brominated fluorocarbon. Prepd not claimed: FR 1512068; L. A. Loree, US 3456024 (1968, 1969 both to Dow Corning). Radiopacity and toxicology: D. M. Long et al., Radiology 105, 323 (1972). Biodistribution and determn in plasma and tissue: F. H. Lee et al., J. Pharm. Sci. 67, 1038 (1978). Clinical trial in abdominal imaging: R. F. Mattrey, Radiology 191, 841 (1994). Toxicity studies: A. R. Burgan et al., Biomater. Artif. Cells Artif. Organs 16, 681 (1988). Review of physicochemical properties and therapeutic potential: D. M. Long et al., ibid. 411-420; of oxygen delivery characteristics: J. G. Riess, ibid. 20, 183-202 (1992).
Properties: Liquid, bp760 141°. d25 1.928. Vapor pressure (37.5°) 14 torr. Surface tension 18.2 dynes/cm. Insol in water. LD50 i.v. in female rats: 41 g/kg (Burgan).
Boiling point: bp760 141°
Density: d25 1.928
Toxicity data: LD50 i.v. in female rats: 41 g/kg (Burgan)
Therap-Cat: Diagnostic aid (contrast agent).
Keywords: Diagnostic Aid (MRI Contrast Agent). |